Journal of Medicinal Chemistry p. 218 - 222 (1983)
Update date:2022-08-03
Topics: Chemical Compounds Experimental Antiinflammatory Agents
Haviv, Fortuna
DeNet, Robert W.
Michaels, Raymond J.
Ratajczyk, James D.
Carter, George W.
Young, Patrick R.
2-<(Phenylthio)methyl>pyridine derivatives (1a-e) inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat.In the same model, indomethacin was inactive, and hydrocortisone was active.Compounds 1a-d also significantly reduced exudate volume and white blood cell accumulation in the pleural RPAR.This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin.
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