Journal of Pharmaceutical Sciences p. 1062 - 1064 (1982)
Update date:2022-08-04
Topics:
Goebel
Currie
Bowers
Three analogs of thyroliberin (I) were prepared. These compounds, N-m-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIa), N-p-chloroacetylbenzoyl-phenylalanyl-prolineamide (VIb) and N-chloroacetyl-alanyl-phenylalanyl-prolineamide (IX), were designed as potential I antagonist affinity labels. However, no significant antagonist activity was observed. Compounds VIa and IX were found to have weak agonist activity. Cyclo (Phe-Pro) an analog of the I metabolite, cyclo (His-Pro), was found, however, to have significant I antagonist activity, but no agonist activity.
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Doi:10.1002/ardp.19823151109
(1982)Doi:10.1016/S0040-4039(00)87626-1
(1982)Doi:10.1055/s-2004-834867
(2004)Doi:10.1021/ja040141r
(2005)Doi:10.1021/ol005502w
(2000)Doi:10.1021/jm8007097
(2008)
