Synthesis of the Carbapenam System from Glutamic Acid and Acetoacetic Acid Derivatives

DOI: 10.1021/jo00157a010

Source and publish data:

Journal of Organic Chemistry p. 1439 - 1444 (1983)

Update date:2022-08-03

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Authors:

Bachi, Mario D.

Breiman, Ron

Meshulam, Haim

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Article abstract of DOI:10.1021/jo00157a010

A synthesis of carbapenam-3-carboxylates is described.Ethyl pyroglutamate was converted into the corresponding thioamide 6 which was subjected to an alkylative sulfide contraction with ethyl 2-bromoacetoacetate.The resulting enamino keto ester 7 was hydro

Full text of DOI:10.1021/jo00157a010

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