Synthesis of the Carbapenam System from Glutamic Acid and Acetoacetic Acid Derivatives

DOI: 10.1021/jo00157a010

Source and publish data:

Journal of Organic Chemistry p. 1439 - 1444 (1983)

Update date:2022-08-03

Topics:

Authors:

Bachi, Mario D.

Breiman, Ron

Meshulam, Haim

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00157a010

A synthesis of carbapenam-3-carboxylates is described.Ethyl pyroglutamate was converted into the corresponding thioamide 6 which was subjected to an alkylative sulfide contraction with ethyl 2-bromoacetoacetate.The resulting enamino keto ester 7 was hydro

Full text of DOI:10.1021/jo00157a010

Products guided by the article

Product name:5,10-Diethyl-4,9-dioxo-dodecahydro-3a,8a-diaza-dicyclopenta[a,e]cyclooctene-3,8-dicarboxylic acid bis-(4-nitro-benzyl) ester

Cas No:84911-33-1

R&D Labs maybe for 84911-33-1

Hubei Sky Lake Chemical Co., Ltd.

Contact:+86-27-87385545

Address:Te-2, Xijiao Chemical Park, Yuekou Town, Tianmen, Hubei, China.
Tianjin Bright Future Technology Co., Ltd

Contact:0086-22-58016666

Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
Shandong Topscience Biotech Co., Ltd.

Contact:0633-2619278

Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Wuhan Soleado Technology Co.,Ltd.

Contact:86-2783341481 18971291927

Address:RM2405 Unit 1 Builing 1, Taiyin Tower, Changqing Road,Wuhan China

Relevant to this article

Doi:10.1021/ja00346a043
(1983)
Asymmetric alkynyl additions to aldehydes catalyzed by tunable oxovanadium(V) complexes of Schiff bases of β-amino alcohols

Doi:10.1055/s-2006-948195
(2006)
Synthesis and stereoselective glycosylation of D- and L-glycero-β-D- manno-heptopyranoses

Doi:10.1021/ol050224s
(2005)
Inversion of Reactivity (Umpolung) of α,β-Ethylenic Ketones and Aldehydes. Electrochemical Deprotection of γ-Thioacetalated Phosphonium Salts

Doi:10.1021/jo00157a028
(1983)
Phosphine-catalyzed synthesis of 1,3-dioxan-4-ylidenes

Doi:10.1021/ol050203y
(2005)
Routes to mitomycins. New syntheses of the 2,3,5,8-tetrahydro-5,8-dioxo-1H-pyrrol[1,2-a]indole ring system. An efficient synthesis of 7-methoxymitosene

Doi:10.1021/ja00347a055
(1983)

Article Doi