Journal of the American Chemical Society
chiral 3-amino skipped diynes, we believe these building
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(11) The catalytic enantioselective synthesis of diarylmethylamines has
blocks will find application in a variety of areas and to this
end we have demonstrated several preliminary applications.
The method should enable the synthesis of more complex
primary amine and polyamine natural products. These stud-
ies, as well as detailed mechanistic investigations are ongoing
in our laboratories and will be reported in due course.
been extensively explored. For a review see: (a) Schmidt, F.; Stemmler,
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(13) Nugent, T. C.; El-Shazly, M. Adv. Synth. Catal. 2010, 352, 753.
(14) Pirnot, M. T.; Wang, M-T.; Buchwald, S. L. Angew. Chem. Int.
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(15) Xi, Y.; Butcher, T. W.; Zhang, J.; Hartwig, J. F. Angew. Chem. Int.
Ed. 2016, 55, 776.
ASSOCIATED CONTENT
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Supporting Information. Experimental procedures and
spectral data for all new compounds. Crystallographic data for
ent-9b (CIF). This material is available free of charge via the
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(16) Enantioselective preparation of skipped diynes is scarce: (a)Anand,
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AUTHOR INFORMATION
Corresponding Author
*aponick@chem.ufl.edu
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
We thank the National Science Foundation (CHE-1362498)
and the University of Florida for their generous support of our
programs.
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