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An approach towards the synthesis of sialyl nucleoside mimetics

DOI: 10.1016/j.tetasy.2005.01.035

Source and publish data:

Tetrahedron Asymmetry p. 1425 - 1434 (2005)

Update date:2022-08-05

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Authors:

Grice, I. DarrenGrice, I. Darren

Whelan, CatherineWhelan, Catherine

Tredwell, Gregory D.Tredwell, Gregory D.

Von Itzstein, MarkVon Itzstein, Mark

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Article abstract of DOI:10.1016/j.tetasy.2005.01.035

An approach towards the synthesis of novel sialyl nucleoside mimetics based on d-fructose is described. The synthesis of these mimetics is achieved in good overall yield in seven steps. The key synthetic step is the coupling reaction of pyrimidine bases (uracil, 5-fluorouracil and cytosine) to the C-1 position of the modified D-tagatofructofuranoside.

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Full text of DOI:10.1016/j.tetasy.2005.01.035

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Product name:[(1R,2S,4S,5S)-4-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-4-methoxy-3,6-dioxa-bicyclo[3.1.0]hex-2-ylmethylsulfanyl]-phenyl-acetic acid methyl ester

Cas No:853017-78-4

853017-78-4

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