
Tetrahedron Letters p. 1803 - 1806 (1999)
Update date:2022-09-26
Topics:
Gaunt, Matthew J.
Boschetti, Carlos E.
Yu, Jinquan
Spencer, Jonathan B.
Selective hydrogenolysis of 2-naphthylmethyl (NAP) esters in the presence of a benzyl ester has been observed with a wide range of dicarboxylic acids. Orthogonal deprotection of NAP esters with challenging substrates can be achieved if the other carboxylic acids in the molecule are protected with 4-trifluoromethyl benzyl group instead of benzyl groups.
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