Journal of Medicinal Chemistry p. 3163 - 3166 (2007)
Update date:2022-07-29
Topics:
Tang, Guozhi
Ding, Ke
Nikolovska-Coleska, Zaneta
Yang, Chao-Yie
Qiu, Su
Shangary, Sanjeev
Wang, Renxiao
Guo, Jie
Gao, Wei
Meagher, Jennifer
Stuckey, Jeanne
Krajewski, Krzysztof
Jiang, Sheng
Roller, Peter P.
Wang, Shaomeng
Structure-based strategy was employed to design flavonoid compounds to mimic the Bim BH3 peptide as a new class of inhibitors of the anti-apoptotic Bcl-2 proteins. The most potent compound, 4 (BI-33), binds to Bcl-2 and Mcl-1 with Ki values of
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