Journal of Pharmaceutical Sciences p. 745 - 751 (1984)
Update date:2022-08-05
Topics:
Shealy
Frye
O'Dell
Thorpe
Kirk
Coburn Jr.
Sporn
Several 13-cis-retinamides were synthesized from 13-cis-retinoic acid via either 13-cis-retinoyl chloride or 13-cis-1-retinoylimidazole. All-trans-retinoylglycine was prepared from all-trans-retinoyl chloride and ethyl glycinate. Detailed procedures were developed for the preparation of other all-trans-retinamides on a large scale for studies of the chemoprevention of cancer.
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