IMPROVED ASYMMETRIC SYNTHESIS OF (-)-3-AMINOCARDICINIC ACID AND FURTHER OBSERVATIONS OF THE MITSUNOBU REACTION FOR β-LACTAM FORMATION IN SERYL PEPTIDES

Article abstract of DOI:10.1016/S0040-4039(00)85732-9

Protected seryl peptide 2 was treated under a variety of conditions with triphenylphosphine or triethylphosphine and diethyl azodicarboxylate to give mechanistic insight into the β-lactam forming reaction and an improved route to (-)-3-aminocardicinic aci