Novel α,α-difluorohomophthalimides via copper-catalyzed tandom cross-coupling-cyclization of 2-halobenzamides with α,α-difluoro reformatskii reagent

Article abstract of DOI:10.1021/jo050599r

Novel α,α-difluorohomophthalimides 2 were prepared by reacting N-substituted 2-halobenzamides with the α,α-difluoro Reformatskii reagent BrZnCF₂CO₂Et (3) in the presence of CuBr at room temperature. The synthesis involves a CuBr-medi