Base-induced Cyclization of N--2-bromo-3-hydroxybutyramide Derivatives

DOI: 10.1246/bcsj.57.2135

Source and publish data:

Bulletin of the Chemical Society of Japan p. 2135 - 2139 (1984)

Update date:2022-09-26

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Authors:

Shiozaki, Masao

Ishida, Noboru

Hiraoka, Tetsuo

Maruyama, Hiroshi

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Article abstract of DOI:10.1246/bcsj.57.2135

Treatment of (2R,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-hydroxybutyramide (5) with DBU yielded the bicyclic β-lactam 13 by a direct cyclization, and its diastereoisomer 14 and the γ-lactam 15 via the trans-epoxide 6.The same t

Full text of DOI:10.1246/bcsj.57.2135

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