Base-induced Cyclization of N--2-bromo-3-hydroxybutyramide Derivatives

Article abstract of DOI:10.1246/bcsj.57.2135

Treatment of (2R,3R)-N-(2,4-dimethoxybenzyl)-N--2-bromo-3-hydroxybutyramide (5) with DBU yielded the bicyclic β-lactam 13 by a direct cyclization, and its diastereoisomer 14 and the γ-lactam 15 via the trans-epoxide 6.The same t