Structure-activity relationships of antimalarial indoloquinolines

Article abstract of DOI:10.1016/0223-5234(93)90036-E

Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindolo<3,2-c>quinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indolo<3,2-c>quinolines <1,2> / antimalarial agents