European Journal of Medicinal Chemistry p. 837 - 852 (1993)
Update date:2022-07-31
Topics:
Werbel, L. M.
Kesten, S. J.
Turner, W. R.
Structure-activity relationships have been ascertained and chemical metodology developed for a series of antimalarial 3-chloroindolo<3,2-c>quinoline-5-oxides.The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3.Substitution at positions 7,8,9,10 in not essential, although the most potent analog in our studies was the 8-nitro compound 4vv. indolo<3,2-c>quinolines <1,2> / antimalarial agents
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