A GENERAL APPROACH TO TRANS-CARBAPENEM ANTIBIOTICS. ENANTIOSELECTIVE SYNTHESIS OF KEY INTERMEDIATES FOR (+)-PS-5, (+)-PS-6, AND (+)-THIENAMYCIN

Article abstract of DOI:10.1016/S0040-4039(00)81369-6

(S)-4-<(Methoxycarbonyl)methyl>-2-azetidinone prepared by chemico-enzymatic approach has been efficiently converted to key intermediates for the synthesis of natural trans-carbapenem antibiotics, (+)-PS-5, (+)-PS-6, and (+)-thienamycin.