Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines

DOI: 10.1021/jm00364a006

Source and publish data:

Journal of Medicinal Chemistry p. 1365 - 1369 (1983)

Update date:2022-07-30

Topics:

Authors:

Brossi Brossi

Sharma Sharma

Atwell Atwell

Jacobson

Iorio Iorio

Molinari

Chignell

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Article abstract of DOI:10.1021/jm00364a006

A series of natural and synthetic colchicine derivatives was examined for their potency in the lymphocytic leukemia P388 screen in mice, for their toxicity in mice, and for their binding to microtubule protein. The natural alkaloids cornigerine and colchi

Full text of DOI:10.1021/jm00364a006

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