Synthesis of some new 2-substituted 3-[4-(N'-arylsulphonylbiguanido)phenyl]quinazolin-4-one hydrochlorides as potential anthelminthic agents

Article abstract of DOI:10.1002/ardp.19833160610

The title compounds 3-37 have been synthesised. Their in vivo cestodicidal activities were evaluated against Hymenolepis nana infection in rats. Compound 32 was found to be the most active of the series showing 81.0% clearance of infection at a dose of 250 mg/kg for 3 days.