The chemistry of clavulanic acid: Some reactions of esters under neutral, acidic and basic conditions

DOI: 10.1016/S0040-4039(00)87979-4

Source and publish data:

Tetrahedron Letters p. 2693 - 2696 (1983)

Update date:2022-07-29

Topics: Ester Nucleophile Rearrangement Clavulanic acid Ring cleavage Thioether Neutral Conditions Acidic Conditions Basic Conditions

Authors:

Brown Brown

Howarth Howarth

Ponsford

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Article abstract of DOI:10.1016/S0040-4039(00)87979-4

Investigations into the chemistry of benzyl clavulanate under a variety of reaction conditions has led to acid catalysed one-step conversion to ether and thioether derivatives. Generation of nitrogen-containing displacement products proceeds via the react

Full text of DOI:10.1016/S0040-4039(00)87979-4

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