PROTECTION OF THE TRYPTOPHAN INDOLE RING IN PEPTIDE SYNTHESIS. USE OF A NEW DERIVATIVE, Nin-2,2,2-TRICHLOROETHOXYCARBONYLTRYPTOPHAN

DOI: 10.1246/cl.1983.739

Source and publish data:

Chemistry Letters p. 739 - 742 (1983)

Update date:2022-09-26

Topics:

Authors:

Kiso, Yoshiaki

Inai, Masatoshi

Kitagawa, Kouki

Akita, Tadashi

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Article abstract of DOI:10.1246/cl.1983.739

The 2,2,2-trichloroethoxycarbonyl (Troc) group attached at the Nⁱⁿ function of tryptophan by acylation with Troc-Cl in the presence of a catalytic amount of tetra-n-butylammonium hydrogensulfate can be quantitatively removed either by cadmium dust in acetic acid or under basic conditions, e. g., hydrazine hydrate and NaOH, but is resistant to strong acidic conditions.

Full text of DOI:10.1246/cl.1983.739

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