Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists

DOI: 10.1021/jm0490686

Source and publish data:

Journal of Medicinal Chemistry p. 6803 - 6812 (2005)

Update date:2022-08-03

Topics:

Authors:

Buck, Ildiko M.

Black, James W.

Cooke, Tracey

Dunstone, David J.

Gaffen, John D.

Griffin, Eric P.

Harper, Elaine A.

Hull, Robert A. D.

Kalindjian, S. Barret

Lilley, Elliot J.

Linney, Ian D.

Low, Caroline M. R.

McDonald, Iain M.

Pether, Michael J.

Roberts, Sonia P.

Shankley, Nigel P.

Shaxted, Mark E.

Steel, Katherine I. M.

Sykes, David A.

Tozer, Matthew J.

Watt, Gillian F.

Walker, Martin K.

Wright, Laurence

Wright, Paul T.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm0490686

The systematic optimization of the structure of a novel 2,4,5-trisubstituted imidazole-based cholecystokinin-2 (CCK₂) receptor antagonist afforded analogues with nanomolar receptor affinity. These compounds were now comparable in their potency

Full text of DOI:10.1021/jm0490686

Products guided by the article

Product name:5-adamantan-1-yl-3-oxo-2-(2-oxo-2-o-tolyl-ethyl)-pentanoic acid ethyl ester

Cas No:869996-80-5

R&D Labs maybe for 869996-80-5

Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)

Contact:18957018777 +86-570-3888777

Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.

Contact:15967177856

Address:Genglou Industrial Development Area
Jiangsu Seed Chem Co.,Ltd.

Contact:86-513-84128750/13773795976

Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China
Hangzhou TJM Chemical Trade Co., Ltd

Contact:86-571-88223276 86-13388481653

Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Langchem

Contact:+86+21-58956006 15800617331

Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai

Relevant to this article

A formal synthesis of (+)-lactacystin

Doi:10.1039/b508300a
(2005)
4-Hydroxy-3-methoxymethamphetamine glucuronide as a phase II metabolite of 3,4-methylenedioxymethamphetamine: Enzyme-assisted synthesis and involvement of human hepatic uridine 5′-diphosphate-glucuronosyltransferase 2B15 in the glucuronidation

Doi:10.1248/cpb.57.472
(2009)
Separation of fencamfamine into diastereomers and synthesis of some of its metabolites

Doi:10.1002/ardp.19943270505
(1994)
NADPH: BIOCHANIN A OXIDOREDUCTASE FROM THE FUNGUS FUSARIUM JAVANICUM

Doi:10.1016/S0031-9422(00)83862-5
(1987)
Towards a New Type of HMG-CoA Reductase Inhibitors: Part II: Dramatic Substituent Effects in the C-5 Epimerisation of Carbohydrate Derivatives

Doi:10.1016/S0040-4020(01)80508-1
(1993)
Synthesis of inositol phospholipids with thiophosphoester bonds

Doi:10.1016/0040-4039(93)88048-N
(1992)

Article Doi