Desulphurative approaches to penem antibiotics. I. 4-acyldithioazetidin-2-ones via thermolysis of penicillin-derived sulphoxides

DOI: 10.1016/S0040-4039(00)81727-X

Source and publish data:

Tetrahedron Letters p. 1623 - 1626 (1983)

Update date:2022-07-29

Topics:

Authors:

Alpegiani

Bedeschi

Foglio Foglio

Perrone Perrone

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Article abstract of DOI:10.1016/S0040-4039(00)81727-X

Thermolysis of penicillin-derived sulphoxides in the presence of thioacids offers a simple route to 4-acyldithioazetidin-2-ones, whose desulphurisation yields key intermediates for the synthesis of penem antibiotics.

Full text of DOI:10.1016/S0040-4039(00)81727-X

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Product name:2-{(2S,3S)-3-((R)-1-Benzyloxycarbonyloxy-ethyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-acetylsulfanyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid benzyl ester

Cas No:87068-02-8

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