Tetrahedron p. 2255 - 2258 (1983)
Update date:2022-08-03
Topics:
Vargha, H. S.
Medzihradszky-Schweiger, H.
Ruff, F.
Medzihradszky, K.
Intramolecular cyclization of the N-(2-chloroethylcarbamoyl) derivatives of glycine, valine and phenylalanine give imidazolidone, oxazoline and hydantoin derivatives.The imidazolidone and oxazoline derivatives possess alkylating activity toward NBP, but the hydantoins do not.N-(2-Chloroethylcarbamoyl)glycine reacts with the mercapto group of cysteine; thus, this alkylating group may be useful for receptor labelling.
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(1983)
