Bioorganic and Medicinal Chemistry Letters p. 1060 - 1064 (2006)
Update date:2022-08-04
Topics:
Kohrt, Jeffrey T.
Filipski, Kevin J.
Cody, Wayne L.
Cai, Cuiman
Dudley, Danette A.
Van Huis, Chad A.
Willardsen, J. Adam
Narasimhan, Lakshmi S.
Zhang, Erli
Rapundalo, Stephen T.
Saiya-Cork, Kamlai
Leadley, Robert J.
Edmunds, Jeremy J.
The activated factor VII/tissue factor complex (FVIIa/TF) is known to play a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered whi
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