3'-Arylspiro-3-ones and Their Conversion to 2-(3-Arylisoxazol-5-yl)benzoates

DOI: 10.1021/jo00172a030

Source and publish data:

Journal of Organic Chemistry p. 4590 - 4592 (1983)

Update date:2022-08-05

Topics:

Authors:

Liu, Kou-Chang

Howe, Robert K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00172a030

A new, convenient route to the biologically active 2-(3-arylisoxazol-5-yl)benzoates 4 is reported.This route consists of 1,3-dipolar cycloaddition of aromatic nitrile oxides to 3-methylenephthalide to form the novel 3'-arylspiro-3-ones 3 and subsequent high-yield conversions of 3 to 4.

Full text of DOI:10.1021/jo00172a030

Products guided by the article

Product name:3'-(3-nitrophenyl)spiro-3-one

Cas No:87413-28-3

R&D Labs maybe for 87413-28-3

Hunan Haili Chemical Industry Co.,Ltd.

Contact:+86-731-85521860

Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
sichuan tiancai fine co LTD.

website:http://www.tcfinechem.com/

Contact:18681346930

Address:baifu town,whou district
Anqing World Chemical Co., Ltd.

Contact:+86-556-5800026

Address:Daguan Economic Development Zone of circular economy industrial park Anqing City Anhui province
Hangzhou Sartort Biopharma Co., Ltd

website:http://www.sartort.com

Contact:86-571-87039693

Address:No. 57, Tech Park Road, Hangzhou, Zhejiang, China
Zhejiang Newfine Industry Co.,Ltd.

Contact:+86-573-82262042

Address:No.225,Dongqing Road, garoms@163.com

Relevant to this article

Enantiospecific first total synthesis of (+)-2β-hydroxysolanascone, the aglycone of the phytoalexin isolated from flue-cured tobacco leaves

Doi:10.1016/j.tetlet.2005.11.014
(2006)
Ortho effect in the Bergman cyclization: Interception of p-benzyne intermediate by intramolecular hydrogen abstraction

Doi:10.1021/jo051857n
(2006)
Synthesis of 3-iodoindoles by the Pd/Cu-catalyzed coupling of N,N-dialkyl-2-iodoanilines and terminal acetylenes, followed by electrophilic cyclization

Doi:10.1021/jo051549p
(2006)
Synthesis and evaluation of in vitro antiplatelet aggregation activities of 2-Methoxy-5-Aminobenzamides

Doi:10.2174/1570180816666181128105044
(2019)
Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression

Doi:10.1021/acschemneuro.6b00337
(2016)
A NEW SYNTHETIC METHOD OF UNSYMMETRICAL α-AMINOAZINES BY THE REACTION OF ALDEHYDE ARENESULFONYL HYDRAZONES WITH α-AMINO-α-ARYLACETONITRILES

Doi:10.1246/cl.1983.993
(1983)

Article Doi