3'-Arylspiro-3-ones and Their Conversion to 2-(3-Arylisoxazol-5-yl)benzoates

DOI: 10.1021/jo00172a030

Source and publish data:

Journal of Organic Chemistry p. 4590 - 4592 (1983)

Update date:2022-08-05

Topics:

Authors:

Liu, Kou-Chang

Howe, Robert K.

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Article abstract of DOI:10.1021/jo00172a030

A new, convenient route to the biologically active 2-(3-arylisoxazol-5-yl)benzoates 4 is reported.This route consists of 1,3-dipolar cycloaddition of aromatic nitrile oxides to 3-methylenephthalide to form the novel 3'-arylspiro-3-ones 3 and subsequent high-yield conversions of 3 to 4.

Full text of DOI:10.1021/jo00172a030

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