5-p-Benzoquinonyl-2'-deoxyuridine-5'-phosphate: A possible mechanism-based inhibitor of thymidylate synthetase

Article abstract of DOI:10.1021/jm00361a016

The title compound (91), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver(II) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate sy