5-p-Benzoquinonyl-2'-deoxyuridine-5'-phosphate: A possible mechanism-based inhibitor of thymidylate synthetase

DOI: 10.1021/jm00361a016

Source and publish data:

Journal of Medicinal Chemistry p. 1028 - 1036 (1983)

Update date:2022-07-29

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Authors:

Maggiora

Chang Chang

Hasson Hasson

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Article abstract of DOI:10.1021/jm00361a016

The title compound (91), designed as a suicide inhibitor of thymidylate synthetase, can be prepared by silver(II) oxide oxidative demethylation of the corresponding dimethoxyphenyl derivative. Compound 1 shows time-dependent inactivation of thymidylate sy

Full text of DOI:10.1021/jm00361a016

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