Journal of Organic Chemistry p. 4337 - 4345 (1983)
Update date:2022-08-04
Topics:
Nakazaki, Masao
Chikamatsu, Hiroaki
Fujii, Takeo
Sasaki, Yasuyuki
Ao, Shizuo
For elucidation of the origin of the inertness exhibited by 2-twist-brendanone type ketones 1 toward microbial and HLADH-catalyzed reductions, the stereochemistry of the oxidoreduction of 2-brendanone type ketones 5 and the related alcohols 14 was studied by preparative-scale incubation experiments.Oxidoreduction of 2-brendanone type substrates 5 and 14 by the HLADH-NAD(+) system was found to proceed with much higher rates than those of the 2-twist-brendanone type substrates 1 and 10.The steric courses found in these enzymatic processes were compared with those of microbial processes.
View MoreHaiNan Periwinkle Pharmaceutical Co.,Ltd.
website:http://www.cchpharm.com/en/index.html
Contact:020-82208978
Address:Gongye road,Wuzhishan city,HaiNan province
shanghai Tauto Biotech Co., Ltd
website:http://www.tautobiotech.com/en/index.htm
Contact:+86-21-51320588 ext. 8025
Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
Wuhan Yitongtai Science and Technology Co.,Ltd.
Contact:+86-27-88933550
Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
Shenyang Mole pharmaceutical Technology Development Co.,Ltd
Contact:+86-24-31204918/13889278616
Address:No.44, wanliutang road, shenhe District of Shenyang
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Doi:10.1021/jm00153a011
(1986)Doi:10.1021/ja00264a027
(1986)Doi:10.1021/jo00355a004
(1986)Doi:10.1039/c9ob01553a
(2019)Doi:10.1021/jo50017a004
(1953)Doi:10.1080/10426507.2014.906425
(2014)
