Synthesis of Acyl Phosphonate Analogues of Biologically Important Acyl Phosphates: N-(2-Amino-10-methylpteroyl)-5-amino-2-oxopentanephosphonic Acid

Article abstract of DOI:10.1021/jo00173a041

The synthesis of several β-keto phosphonates has been effected by the reaction of the carbanion derived from dimethyl methanephosphonate with appropriately substituted carboxylic acid esters.The presence of nucleophilic substituents γ to the ketone in β-k