Dealkylation of a Tertiary Amine Group by an Intramolecular Carbamyl Chloride Functionality

DOI: 10.1021/jo00173a054

Source and publish data:

Journal of Organic Chemistry p. 5074 - 5080 (1983)

Update date:2022-07-29

Topics:

Authors:

Maryanoff, Bruce E.

Molinari, Albert J.

McComsey, David F.

Maryanoff, Cynthia A.

Wooden, Gary P.

Olofson, R. A.

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Article abstract of DOI:10.1021/jo00173a054

Compounds containing a 4-anilinopiperidine moiety react with phosgene to afford carbamyl chloride hydrochloride derivatives, which rearrange in the presence of nonnucleophilic amine bases.The rearrangement entails intramolecular acylation by the carbamyl

Full text of DOI:10.1021/jo00173a054

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