Synthesis of β-lactam antibiotics by the sulfeno-cycloamination

Article abstract of DOI:10.1021/ja00363a023

A novel efficient beta -lactam synthesis was achieved by two successive processes (sulfeno-cycloamination), addition of phenysulfenyl chloride to alpha , beta -unsaturated amides followed by base treatment. Key synthetic intermediates of monobactams and nocardicin derivatives were obtained via this method. construction of the 1-carbapenam ring system by the sulfenocycloamination is also described.