Journal of Medicinal Chemistry p. 714 - 717 (1985)
Update date:2022-08-05
Topics:
Miyano, Seiji
Sumoto, Kunihiro
Satoh, Fumio
Shima, Keiyu
Hayashimatsu, Mariko
et al.
The synthesis and antiarrhytmic activity of N-aryl-8-pyrrolizidinealkanamides are described.The targed compounds were evaluated for their ability to protect against chloroform-induced fibrillation in mice.Many of them were found to have antifibrillatory activity comparable to that of lidocaine; several are more potent than lidocaine.N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide (6n), which was found to be more potent and less toxic (LD50) than lidocaine, also showed a long duration of action in dogs with venticular arrhythmias after oral administration.
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