Studies related to biological detoxification of kraft pulp mill effluent. VII. The biotransformation of 12-chlorodehydroabietic acid with Mortierella isabellina

Article abstract of DOI:10.1002/hlca.19830660730

A detailed study of the biodegradation of one of the fish-toxic chlorinated resin acids, 12-chlorodehydroabietic acid (3), is discussed. When 3 is exposed to the fungus Mortierella isabellina, it is converted into the monohydroxylated metabolites 2α-hydroxy-12-chlorodehydroabietic acid (5) and 16-hydroxy-12-chlorodehydroabietic acid (8) after short-term (26 h) incubation, and into the 2α, 16-dihydroxy derivatives 11 and 14 after 96 h incubation. These metabolites show low levels of toxicity to fish.