Journal of the American Chemical Society p. 1461 - 1467 (1984)
Update date:2022-08-05
Topics:
Bridges
Raman
Ng
Jones
Preparative-scale horse liver alcohol dehydrogenase catalyzed oxidations of meso-1,3-bis(hydroxymethyl)cyclopentyl and -cyclohexyl substrates proceed stereospecifically to give 42-81% yields of the corresponding chiral bridged-bicyclic gamma -lactones of 100% ee. For each diol, oxidation of the hydroxymethyl group attached to the S center occurs exclusively. The stereospecificities observed are as predicted by the active-site model of the enzyme.
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Doi:10.1002/jhet.5570200535
(1983)Doi:10.1016/S0040-4039(00)94520-9
(1983)Doi:10.1021/jo00179a014
(1984)Doi:10.1016/0957-4166(96)00405-3
(1996)Doi:10.1021/jm0700417
(2007)Doi:10.1271/bbb.69.1620
(2005)
