Retro-Inverso Isomerization of Peptides: Side Reactions in the Synthesis of N,N'-Diacyl-1,1-diamino-2-phenylethane Derivatives

DOI: 10.1021/jo00179a014

Source and publish data:

Journal of Organic Chemistry p. 821 - 827 (1984)

Update date:2022-08-05

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Authors:

Chorev, Michael

MacDonald, Scott A.

Goodman, Murray

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Article abstract of DOI:10.1021/jo00179a014

In general, the synthesis of retro-inverso peptides requires the formation of diacylated gem-diaminoalkyl structures.One way to prepare these gem-diaminoalkyl residues involves the Curtius rearrangement of the N-acylated amino acid hydrazides to the corre

Full text of DOI:10.1021/jo00179a014

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Product name:1-Pyrrolidinecarboxylic acid, 2-(1,1-dimethylethoxy)-, phenylmethyl ester, (R)-

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