Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

DOI: 10.1021/acs.jmedchem.5b01493

Source and publish data:

Journal of Medicinal Chemistry p. 1545 - 1555 (2016)

Update date:2022-08-04

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Authors:

Senger, Johanna

Melesina, Jelena

Marek, Martin

Romier, Christophe

Oehme, Ina

Witt, Olaf

Sippl, Wolfgang

Jung, Manfred

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Article abstract of DOI:10.1021/acs.jmedchem.5b01493

Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine residues of several non-histone proteins. Here we report the preparation of thiazole-, oxazole-, and oxadiazole-containing biarylhydroxamic acids by a short synthetic proce

Full text of DOI:10.1021/acs.jmedchem.5b01493

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