Bioorganic and Medicinal Chemistry p. 3320 - 3329 (2006)
Update date:2022-08-04
Topics:
Gu, Wenxin
Nusinzon, Inna
Smith Jr., Ronald D.
Horvath, Curt M.
Silverman, Richard B.
Suberoylanilide hydroxamic acid (SAHA), an inhibitor of histone deacetylase, is used in clinical trials for a variety of advanced cancers. Twelve new analogs of SAHA were synthesized and tested as in vitro inhibitors of isolated histone deacetylases (HDACS) and in vivo inhibitors of interferon regulated transcriptional responses (a marker for HDAC activity). The analogs containing an α-mercaptoketone or an α-thioacetoxyketone were more potent than SAHA in both assays.
View Morewebsite:http://www.orchid-chem.com
Contact:+86-571-85395792
Address:607, North Zhongshan Road, Hangzhou 310000 China
Contact:(86) 731 88718666
Address:Room 1222, Unit 4, Building B, Shangcheng, No.47, Kaiyuan East Road.
Airsea(Taizhou) Pharmaceutical Limited(expird)
Contact:+86-576-88057622
Address:Dubei, Duqiao, Linhai, Taizhou, Zhejiang, China Zip: 317016
Changsha Goomoo Chemical Technology Co.Ltd
Contact:+86-731-82197655
Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Daqing E-shine Chemical Co.,LTD
Contact:0086-024-31285112
Address:Hongweiyuan area, Ranghulu district
Doi:10.1016/S0040-4039(00)94290-4
(1983)Doi:10.1021/jo052325+
(2006)Doi:10.1039/b513717a
(2006)Doi:10.1039/c2gc00006g
(2012)Doi:10.1016/j.carres.2006.01.021
(2006)Doi:10.1039/jr9630006028
(1963)
