Anticoagulant 3-aralkyl-4-hydroxy-2-pyrones

Article abstract of DOI:10.1002/ardp.19833161204

Nine title compounds were synthesized and tested for their anticoagulant activity. After oral administration of a single dose of 330 mg/kg to rats, prothrombin levels below 15% were seen with 6 compounds. With two compounds the same result was obtained when the dose was reduced to 165 mg/kg. With the most active compound, the maximum effect was reached after 12 h and maintained up to 48 h. The existence of tautomeric 2-hydroxy-4-pyrones is discussed.