
Tetrahedron Letters p. 7459 - 7462 (1998)
Update date:2022-08-02
Topics:
Weissman, Steven A.
Lewis, Stephanie
Askin, David
Volante
Reider, Paul J.
A practical two pot synthesis of N-arylpiperazinones from the corresponding aniline is described. The key transformation is a selective intramolecular Mitsunobu cyclodehydration of an amidoalcohol intermediate. A series of N-arylpiperazinones were prepared in yields up to 89%.
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