Tetrahedron Letters p. 6835 - 6836 (1997)
Update date:2022-08-02
Topics:
Taghavi-Moghadam, Shahriyar
Pfleiderer, Wolfgang
A new synthetic method for the preparation of 2,6-disubstituted 4-aminopteridines is described. Treatment of a-substituted 4,5,6-triaminopyrimidines with α-ketoaldoximes in MeOH affords in a regioselective one-step reaction 2,6-disubstituted 4-aminopteridines in high yield.
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