Medicinal Chemistry Research p. 229 - 240 (2005)
Update date:2022-08-03
Topics:
Dubey, Sonal
Jindal
Piplani, Poonam
Young, Louse C.
Fathi, Behrooz
Harvey, Alan L.
This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy function for potent antagonist activity. Birkhaeuser Boston 2006.
View MoreContact:+86+21-58956006 15800617331
Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.
website:http://www.sino-strong.com.cn
Contact:+86-28-82666753
Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
website:http://www.fwdchem.com
Contact:86-21-54450828
Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
Contact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
Jiangxi Hessence Chemicals Co., Ltd.
Contact:+86 796 3511924
Address:Chengxi Industrial Park, Jishui County, Jiangxi Province 331600 China.
Doi:10.1002/ejoc.201300308
(2013)Doi:10.1021/ja01121a012
(1952)Doi:10.1039/jr9320002607
(1932)Doi:10.1002/adsc.201300307
(2013)Doi:10.1007/BF00953089
(1983)Doi:10.1021/jo50015a008
(1953)
