ASYMMETRIC REDUCTION OF ALKYL PHENYL KETONES WITH A CHIRAL HYDRIDE REAGENT PREPARED FROM LITHIUM ALUMINUM HYDRIDE AND (S)-4-ANILINO-3-METHYLAMINO-1-BUTANOL

Article abstract of DOI:10.1016/S0040-4039(00)88361-6

The asymmetric reduction of alkyl phenyl ketones with a chiral hydride reagent derived from lithium aluminum hydride and (S)-4-anilino-3-methylamino-1-butanol, which is prepared from (S)-aspartic acid, gives (S)-alkylphenylcarbinols in high chemical and o