Journal of Chemical and Engineering Data p. 229 - 231 (1984)
Update date:2022-07-31
Topics: Reactants Syntheses Antibacterial activity Minimum inhibitory concentration (MIC) Spectroscopic Analysis Synthesis pathway
Sabri
El-Abadelah
Owais
The syntheses and in vitro and in vivo antibacterial activities of a series of N-(3-methyl-2-quinoxaloyl) amino alcohols and amine 1,4-dioxides, and their deoxygenated analogues, are described. The quinoxaline 1,4-dioxide derivative of the naturally occurring ( minus )-ephedrine was found to be the most potent antibacterial agent of the series. The presence of a hydroxy group and a tertiary amide appears to be associated with enhancement of the antibacterial action.
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