Synthesis of β-chloro α-amino acids: (2S,3R)- and (2S,3S)-3-chloroleucine

Article abstract of DOI:10.1016/j.tetlet.2006.03.127

The first syntheses of (2S,3R)- and (2S,3S)-3-chloroleucine (3-chloro-d-leucines 1 and 2) have been achieved from d-3-hydroxyleucine and allo-d-3-hydroxyleucine, respectively, through the formation of the corresponding N-Cbz β-lactones, followed by a ring