Highly enantioselective catalytic asymmetric synthesis of a (R)-sibutramin precursor

DOI: 10.2533/chimia.2010.59

Source and publish data:

Chimia p. 59 - 64 (2010)

Update date:2022-08-03

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Authors:

Berens, Ulrich

Hafner, Andreas

Dosenbach, Oliver

Tritschler, Tanja

Schwarzenbach, Franz

Kirner, Hans-Jorg

Malan, Christophe

Mai-Huynh, Oanh

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Article abstract of DOI:10.2533/chimia.2010.59

The first highly enantioselective, catalytic asymmetric synthesis of di-des-methylsibutramine 3 is described. Dienamide 10, prepared by acetic acid anhydride quenching of the condensation product of nitrile 4 with a methallyl magnesium chloride, proved to

Full text of DOI:10.2533/chimia.2010.59

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