Journal of Organic Chemistry p. 2405 - 2408 (1986)
Update date:2022-08-04
Topics: Asymmetric synthesis Catalyst Stereochemistry Asymmetric catalysis Alkyl group Chiral compound Proline
Ho, Teresa L.
Gopalan, Balasubramanian
Nestor, John J.
We have developed a versatile and convenient synthesis of cis-5-alkylprolinamides.Protection/activation of the α-carboxylic acid function of N-benzyloxycarbonyl-L-glutamic acid (Z-L-Glu-OH) by reaction with H2CO to form an N-Z-oxazolidinone ring allowed t
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