Bioorganic and Medicinal Chemistry Letters p. 3419 - 3423 (2006)
Update date:2022-08-03
Topics:
Testard, Alexandra
Loge, Cedric
Leger, Benoit
Robert, Jean-Michel
Lozach, Olivier
Blairvacq, Melina
Meijer, Laurent
Thiery, Valerie
Besson, Thierry
In an effort to identify new protein kinase inhibitors with increased potency and selectivity, we have developed the microwave-assisted synthesis of thiazolo[5,4-f]quinazolin-9-ones. The effects of eighteen derivatives on CDK1/cyclin B, CDK5/p25, and GSK-
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