Protein Kinase C Modulators. Indolactams. 1. Efficient and Flexible Routes for the Preparation of (-)-Indolactam V for Use in the Synthesis of Analogs

Article abstract of DOI:10.1016/S0040-4039(00)78433-4

Three syntheses of the protein kinase C activator, (-)-indolactam V, are described and are compared for their potential utility in the preparation of ILV analogs.In one route the 4-amino functionality is introduced regiospecifically during the constructio