Bioorganic and Medicinal Chemistry Letters p. 6982 - 6986 (2011)
Update date:2022-08-04
Topics:
Kim, Seong Heon
Anilkumar, Gopinadhan N.
Zawacki, Lisa Guise
Zeng, Qingbei
Yang, De-Yi
Shao, Yuefei
Dong, Guizhen
Xu, Xiaolian
Yu, Wensheng
Jiang, Yueheng
Jenh, Chung-Her
Hall III, James W.
Carroll, Carolyn Diianni
Hobbs, Doug W.
Baldwin, John J.
McGuinness, Brian F.
Rosenblum, Stuart B.
Kozlowski, Joseph A.
Shankar, Bandarpalle B.
Shih, Neng-Yang
The SAR of a novel pyrazinyl-piperazinyl-piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and reduction of hERG inhibition is described. Compound 16e with single-digit CXCR3 affinity, good rat PK a
View MoreTaixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
Hangzhou Maytime Bio-Tech Co.,Ltd.
website:http://www.maytime.com.cn
Contact:+86-571-88925295 88920965
Address:NO.2-1701 Ganghui Central Ningwei Street, Xiaoshan Hangzhou Zhejiang China
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011，13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
Valiant Fine Chemicals Co., Ltd.
Contact:+86 535 6101878/6374484
Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Doi:10.1021/ja01015a021
(1968)Doi:10.1016/j.tetlet.2006.05.168
(2006)Doi:10.1135/cccc19840285
(1984)Doi:10.1021/jo00191a017
(1984)Doi:10.1021/jo961889y
(1997)Doi:10.1016/j.tetlet.2017.06.043
(2017)
