Synthesis and Kinetic Studies of Protease Substrates Containing the 1-Methyl-6-aminoquinolinium Ion as a Fluorogenic Leaving Group

DOI: 10.1021/jm00375a014

Source and publish data:

Journal of Medicinal Chemistry p. 1166 - 1170 (1984)

Update date:2022-08-04

Topics:

Authors:

Andrade-Gordon, Patricia

Gordon, David

Brynes, Paul J.

Wu, Cheng-Wen

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Article abstract of DOI:10.1021/jm00375a014

Several sensitive substrates for porcine pancreatic elastase, chymotrypsin, and trypsin were prepared that utilize the permanently charged, fluorogenic cation 1-methyl-6-aminoquinoline (MAQ⁺) as the leaving group.Kinetic rates for the hydrolysi

Full text of DOI:10.1021/jm00375a014

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