Synthesis and Kinetic Studies of Protease Substrates Containing the 1-Methyl-6-aminoquinolinium Ion as a Fluorogenic Leaving Group

Article abstract of DOI:10.1021/jm00375a014

Several sensitive substrates for porcine pancreatic elastase, chymotrypsin, and trypsin were prepared that utilize the permanently charged, fluorogenic cation 1-methyl-6-aminoquinoline (MAQ⁺) as the leaving group.Kinetic rates for the hydrolysi