HIGHLY STEREOCONTROLLED SUBSTITUTION OF PHENOLS WITH PYRUVIC ESTERS. A VIABLE ROUTE TO ortho-HYDROXYATROLACTIC ESTERS OF (2R)- AND (2S)-CONFIGURATION

Article abstract of DOI:10.1016/S0040-4039(00)98370-9

Treatment of phenols with optically active (+)- and (-)-menthyl pyruvate assisted by Al(III)- or Ti(IV)-based promoters leads to the formation of ortho-hydroxyatrolactic esters of (2R)- and (2S)-configuration.The use of suitable menthol-based promoters au