
Journal of Organic Chemistry p. 6686 - 6689 (2006)
Update date:2022-08-04
Topics:
Ahmed, Md. Moinuddin
Cui, Hu
O'Doherty, George A.
A short and highly efficient route to both enantiomers of muricatacin as well as the C-5-epimer has been developed. The key to the overall transformation is the highly regio- and enantioselective Sharpless asymmetric dihydroxylation of an (E,Z)-dienoate. The highly efficient stereoselective synthesis prepares (-)-muricatacin in seven steps and 66% overall yield.
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