Design, Synthesis and Protection Against Pentylenetetrazole-induced
Medicinal Chemistry, 2012, Vol. 8, No. 5 963
mmol) provided the title compound, after 10h and recrystal-
lization from ethanol: yield 70%; H NMR (DMSO-d6) ꢀ
ACKNOWLEDGEMENTS
1
We are grateful to the Azad University for financial sup-
port for this research, and to the Professor Arthur J. Olson
and Professor A. Fozzard for their kindness in offering us the
AutoDock 4.2 program and the homology model of sodium
channel. We thank Dr. Mehdi Rajabi for his kindness in
preparation of this paper.
ppm 8.65(dd, J= 8.0 Hz, 1.6 Hz, 1H, H-6), 8.50(d, J= 1.6 Hz,
1H, H-4), 8.15(d, J= 8.0 Hz, 1H, H-7), 7.50-7.60(m, 5H,
phenyl), ; IR (KBr, ꢁ, cm-1) 3090(H-aromatic), 1778, 1711
(C= O phthalimide),1542, 1347 (NO2), Anal. (C14H8N2O4) C,
H, N.
7.4. Molecular Modeling and Docking
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CONFLICT OF INTEREST
The author(s) confirm that this article content has no con-
flicts of interest.
Received: July 12, 2011
Revised: April 1, 2012
Accepted: April 2, 2012