Molecules p. 8832 - 8841 (2012)
Update date:2022-08-04
Topics:
Bi, Yi
Xu, Jinyi
Sun, Fei
Wu, Xiaoming
Ye, Wencai
Sun, Yijun
Huang, Wenwen
23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC50 values of 8.35 μM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.
View MoreContact:0086-21-80264647
Address:RM 202, NO 1602 West Zhongshan Rd, Shanghai, China
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address: Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Shandong LuZhou Amino Acid Co., Ltd
Contact:86-539-2218025
Address:yishui economic and technical development zone zhenxing south road
Shanghai Dynamic Industrial Co.,Ltd.
website:http://www.shdynamic.com
Contact:86-021 3392 6680
Address:Room 805 Information Tower, No.1403 Minsheng Road, Pudong New Area, Shanghai 200135, P. R. China
Shanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
Doi:10.1055/s-0029-1216852
(2009)Doi:10.1002/ejic.200500772
(2006)Doi:10.1016/j.tet.2006.12.049
(2007)Doi:10.1021/ol061952y
(2006)Doi:10.1021/ja00332a049
(1984)Doi:10.1016/S0040-4039(02)01543-5
(2002)