Molecules p. 8832 - 8841 (2012)
Update date:2022-08-04
Topics:
Bi, Yi
Xu, Jinyi
Sun, Fei
Wu, Xiaoming
Ye, Wencai
Sun, Yijun
Huang, Wenwen
23-Hydroxybetulinic acid (1) served as the precursor for the synthesis of C-28 ester derivatives. The target compounds were evaluated in vitro for their antitumor activities against five cell lines (A549, BEL-7402, SF-763, B16 and HL-60). Among the obtained compounds, 6i had the most potent antitumor activity, with the IC50 values of 8.35 μM in HL-60 cells and showed similar antitumor activity as cyclophosphamide in H22 liver tumor and as 5-fluorouracil in B16 melanoma in vivo.
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